3.6M
XNAS Volume
High vol.+loss this week
XNAS 20 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Claude Nicaise | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Mar 2025 | 9,746 | 0 | - | - | Stock Options (right to buy) | |
| Claude Nicaise | Director | Sale of securities on an exchange or to another person at price $ 99.64 per share. | 12 Mar 2025 | 2,491 | 27,812 (0%) | 0% | 99.6 | 248,203 | Common Stock |
| Claude Nicaise | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 25.18 per share. | 12 Mar 2025 | 9,746 | 30,303 (0%) | 0% | 25.2 | 245,404 | Common Stock |
| Deirdre P. Connelly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 5,225 (0%) | 0% | - | Common Stock | |
| Deirdre P. Connelly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 4,792 | - | - | Stock Options (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 193,476 (0%) | 0% | - | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 4,792 | - | - | Stock Option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 20,557 | - | - | Stock Options (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 20,557 (0%) | 0% | - | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 4,792 | - | - | Stock Options (right to buy) | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 25,223 (0%) | 0% | - | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 2,934,071 (3%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 4,792 | - | - | Stock Options (right to buy) | |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 8,263 (0%) | 0% | - | Common Stock | |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 4,792 | - | - | Stock Options (right to buy) | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 9,004 (0%) | 0% | - | Common Stock | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 4,792 | - | - | Stock Options (right to buy) | |
| Michael A. Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 2,383 | 10,660 (0%) | 0% | - | Common Stock | |
| Michael A. Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 4,792 | 4,792 | - | - | Stock Options (right to buy) | |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 10 Mar 2025 | 523 | 24,224 (0%) | 0% | 100.1 | 52,368 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 16,644 | 16,644 | - | - | Stock Options (right to buy) | |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 8,276 | 32,500 (0%) | 0% | - | Common Stock | |
| Cristin Rothfuss | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 8,276 | 21,110 (0%) | 0% | - | Common Stock | |
| Cristin Rothfuss | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 10 Mar 2025 | 491 | 12,834 (0%) | 0% | 100.1 | 49,164 | Common Stock |
| Cristin Rothfuss | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 16,644 | 16,644 | - | - | Stock Options (right to buy) | |
| Cristin Rothfuss | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 07 Mar 2025 | 1,131 | 12,194 (0%) | 0% | 103.7 | 117,285 | Common Stock |
| Cristin Rothfuss | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 07 Mar 2025 | 347 | 11,847 (0%) | 0% | 103.7 | 35,984 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 8,276 | 84,631 (0%) | 0% | - | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 07 Mar 2025 | 2,539 | 76,355 (0%) | 0% | 100.1 | 254,230 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 07 Mar 2025 | 924 | 78,894 (0%) | 0% | 100.1 | 92,520 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 5,500 | 79,818 (0%) | 0% | - | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 16,644 | 16,644 | - | - | Stock Options (right to buy) | |
| Louise Rodino-Klapac | Head of R&D, CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 5,500 | 0 | - | - | Performance Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 07 Mar 2025 | 2,890 | 54,336 (0%) | 0% | 100.1 | 289,376 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 8,276 | 62,612 (0%) | 0% | - | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 5,500 | 0 | - | - | Performance Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 16,644 | 16,644 | - | - | Stock Options (right to buy) | |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 5,500 | 58,277 (0%) | 0% | - | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 07 Mar 2025 | 1,051 | 57,226 (0%) | 0% | 100.1 | 105,237 | Common Stock |
| Dallan Murray | Chief Customer Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 8,276 | 38,202 (0%) | 0% | - | Common Stock | |
| Dallan Murray | Chief Customer Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 5,500 | 33,659 (0%) | 0% | - | Common Stock | |
| Dallan Murray | Chief Customer Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 07 Mar 2025 | 996 | 32,663 (0%) | 0% | 100.1 | 99,729 | Common Stock |
| Dallan Murray | Chief Customer Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 100.13 per share. | 07 Mar 2025 | 2,737 | 29,926 (0%) | 0% | 100.1 | 274,056 | Common Stock |
| Dallan Murray | Chief Customer Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 5,500 | 0 | - | - | Performance Stock Units | |
| Dallan Murray | Chief Customer Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 16,644 | 16,644 | - | - | Stock Options (right to buy) | |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 7,990 | 74,318 (0%) | 0% | 103.7 | 828,563 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 514 | 82,308 (0%) | 0% | 103.7 | 53,302 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 82,822 (0%) | 0% | - | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 0 | - | - | Performance Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 9,094 | 52,777 (0%) | 0% | 103.7 | 943,048 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 585 | 61,871 (0%) | 0% | 103.7 | 60,665 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 62,456 (0%) | 0% | - | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 0 | - | - | Performance Stock Units | |
| Bilal Arif | Chief Tech Ops Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 0 | - | - | Performance Stock Units | |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 508 | 33,274 (0%) | 0% | 103.7 | 52,680 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 33,782 (0%) | 0% | - | Common Stock | |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 8,527 | 24,747 (0%) | 0% | 103.7 | 884,250 | Common Stock |
| Dallan Murray | Chief Customer Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 549 | 36,772 (0%) | 0% | 103.7 | 56,931 | Common Stock |
| Dallan Murray | Chief Customer Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 0 | - | - | Performance Stock Units | |
| Dallan Murray | Chief Customer Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.70 per share. | 06 Mar 2025 | 8,613 | 28,159 (0%) | 0% | 103.7 | 893,168 | Common Stock |
| Dallan Murray | Chief Customer Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 17,500 | 37,321 (0%) | 0% | - | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.34 per share. | 04 Mar 2025 | 1,704 | 65,322 (0%) | 0% | 101.3 | 172,683 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.34 per share. | 04 Mar 2025 | 1,370 | 44,956 (0%) | 0% | 101.3 | 138,836 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.34 per share. | 04 Mar 2025 | 233 | 16,282 (0%) | 0% | 101.3 | 23,612 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.34 per share. | 04 Mar 2025 | 281 | 16,515 (0%) | 0% | 101.3 | 28,477 | Common Stock |
| Dallan Murray | Chief Customer Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.34 per share. | 04 Mar 2025 | 1,685 | 19,821 (0%) | 0% | 101.3 | 170,758 | Common Stock |
| Cristin Rothfuss | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.34 per share. | 04 Mar 2025 | 296 | 13,325 (0%) | 0% | 101.3 | 29,997 | Common Stock |
| Cristin Rothfuss | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.34 per share. | 04 Mar 2025 | 288 | 13,037 (0%) | 0% | 101.3 | 29,186 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.77 per share. | 03 Mar 2025 | 715 | 67,026 (0%) | 0% | 103.8 | 74,196 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.77 per share. | 03 Mar 2025 | 557 | 46,326 (0%) | 0% | 103.8 | 57,800 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.77 per share. | 03 Mar 2025 | 719 | 16,796 (0%) | 0% | 103.8 | 74,611 | Common Stock |
| Dallan Murray | Chief Customer Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.77 per share. | 03 Mar 2025 | 711 | 21,506 (0%) | 0% | 103.8 | 73,780 | Common Stock |
| Cristin Rothfuss | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 103.77 per share. | 03 Mar 2025 | 391 | 13,621 (0%) | 0% | 103.8 | 40,574 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 3,500 | 17,500 | - | - | Performance Restricted Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 3,500 | 17,500 | - | - | Performance Restricted Stock Units | |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 3,500 | 17,500 | - | - | Performance Restricted Stock Units | |
| Dallan Murray | Chief Customer Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 3,500 | 17,500 | - | - | Performance Restricted Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 29 Jan 2025 | 14,267 | 47,963 (0%) | 0% | 12 | 171,204 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 29 Jan 2025 | 1,533 | 49,496 (0%) | 0% | 12 | 18,396 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.51 per share. | 29 Jan 2025 | 2,613 | 46,883 (0%) | 0% | 117.5 | 307,054 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jan 2025 | 14,267 | 0 | - | - | Stock Option (right to buy) | |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jan 2025 | 1,533 | 0 | - | - | Stock Option (right to buy) | |
| Estepan Michael Ian | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Dec 2024 | 250 | 33,696 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2024 | 10,500 | 0 | - | - | Stock Options (right to buy) | |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 124.84 per share. | 12 Dec 2024 | 10,500 | 22,840 (0%) | 0% | 124.8 | 1,310,820 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 12 Dec 2024 | 10,500 | 33,340 (0%) | 0% | 13.7 | 143,955 | Common Stock |
| Kathryn Jean Boor | Director | Sale of securities on an exchange or to another person at price $ 125.55 per share. | 05 Dec 2024 | 1,636 | 5,880 (0%) | 0% | 125.6 | 205,400 | Common Stock |
| Cristin Rothfuss | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Nov 2024 | 4,000 | 4,000 | - | - | Stock Option (right to buy) | |
| Rothfuss Cristin | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Nov 2024 | 2,000 | 13,817 (0%) | 0% | 0 | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 102.89 per share. | 18 Nov 2024 | 4,558 | 67,630 (0%) | 0% | 102.9 | 468,973 | Common Stock |
| Deirdre P. Connelly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2024 | 6,442 | 6,442 | - | - | Stock Option (right to buy) | |
| Deirdre P. Connelly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2024 | 2,842 | 2,842 (0%) | 0% | 0 | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Sep 2024 | 746 | 191,093 (0%) | 0% | 0 | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 137.36 per share. | 30 Aug 2024 | 5,985 | 33,946 (0%) | 0% | 137.4 | 822,100 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 134.06 per share. | 16 Aug 2024 | 18,284 | 278,386 (0%) | 0% | 134.1 | 2,451,153 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 134.66 per share. | 16 Aug 2024 | 5,648 | 284,034 (0%) | 0% | 134.7 | 760,560 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 133.07 per share. | 16 Aug 2024 | 13,106 | 260,102 (0%) | 0% | 133.1 | 1,744,015 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2024 | 15,000 | 0 | - | - | Stock Option (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.90 per share. | 03 Jul 2024 | 15,000 | 191,839 (0%) | 0% | 13.9 | 208,500 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.64 per share. | 21 Jun 2024 | 2,182 | 72,141 (0%) | 0% | 164.6 | 359,244 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 74,323 (0%) | 0% | - | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 0 | - | - | Performance Stock Units | |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 6,250 | - | - | Performance Stock Units | |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 5,500 | 5,500 | - | - | Performance Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 5,500 | 5,500 | - | - | Performance Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 0 | - | - | Performance Stock Units | |
| Ian Michael Estepan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 42,414 (0%) | 0% | - | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.64 per share. | 21 Jun 2024 | 2,483 | 39,931 (0%) | 0% | 164.6 | 408,801 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 6,250 | - | - | Performance Stock Units | |
| Ryan Edward Brown | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 34,938 (0%) | 0% | - | Common Stock | |
| Ryan Edward Brown | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 23,500 | 0 | - | - | Stock Option (right to buy) | |
| Ryan Edward Brown | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 0 | - | - | Performance Stock Units | |
| Ryan Edward Brown | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 5,500 | 5,500 | - | - | Performance Stock Units | |
| Ryan Edward Brown | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 6,250 | - | - | Performance Stock Units | |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 164.52 per share. | 21 Jun 2024 | 2,549 | 17,129 (0%) | 0% | 164.5 | 419,361 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 163.53 per share. | 21 Jun 2024 | 3,840 | 19,678 (0%) | 0% | 163.5 | 627,955 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 162.65 per share. | 21 Jun 2024 | 17,581 | 23,518 (0%) | 0% | 162.7 | 2,859,550 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 161.82 per share. | 21 Jun 2024 | 4,168 | 41,099 (0%) | 0% | 161.8 | 674,466 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 160.31 per share. | 21 Jun 2024 | 975 | 45,267 (0%) | 0% | 160.3 | 156,302 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 159.14 per share. | 21 Jun 2024 | 2,200 | 46,242 (0%) | 0% | 159.1 | 350,108 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 158.07 per share. | 21 Jun 2024 | 7,644 | 48,442 (0%) | 0% | 158.1 | 1,208,287 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 62.77 per share. | 21 Jun 2024 | 23,500 | 56,086 (0%) | 0% | 62.8 | 1,475,095 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.64 per share. | 21 Jun 2024 | 2,352 | 32,586 (0%) | 0% | 164.6 | 387,233 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 31,472 (0%) | 0% | - | Common Stock | |
| Bilal Arif | Chief Tech Ops Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 0 | - | - | Performance Stock Units | |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 6,250 | - | - | Performance Stock Units | |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 163.23 per share. | 21 Jun 2024 | 3,898 | 17,363 (0%) | 0% | 163.2 | 636,271 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 167.13 per share. | 21 Jun 2024 | 224 | 21,261 (0%) | 0% | 167.1 | 37,437 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 166.10 per share. | 21 Jun 2024 | 700 | 21,485 (0%) | 0% | 166.1 | 116,270 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 164.61 per share. | 21 Jun 2024 | 300 | 22,185 (0%) | 0% | 164.6 | 49,383 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 163.83 per share. | 21 Jun 2024 | 1,055 | 22,485 (0%) | 0% | 163.8 | 172,841 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 162.31 per share. | 21 Jun 2024 | 5,580 | 23,540 (0%) | 0% | 162.3 | 905,690 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.64 per share. | 21 Jun 2024 | 2,352 | 29,120 (0%) | 0% | 164.6 | 387,233 | Common Stock |
| Dallan Murray | Chief Customer Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 24,375 (0%) | 0% | - | Common Stock | |
| Dallan Murray | Chief Customer Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.64 per share. | 21 Jun 2024 | 2,352 | 22,023 (0%) | 0% | 164.6 | 387,233 | Common Stock |
| Dallan Murray | Chief Customer Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 5,500 | 5,500 | - | - | Performance Stock Units | |
| Dallan Murray | Chief Customer Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 6,250 | - | - | Performance Stock Units | |
| Dallan Murray | Chief Customer Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 6,250 | 0 | - | - | Performance Stock Units | |
| Dallan Murray | Chief Customer Officer | Sale of securities on an exchange or to another person at price $ 140.00 per share. | 02 May 2024 | 3,635 | 18,125 (0%) | 0% | 140 | 508,900 | Common Stock |
| Kathryn Jean Boor | Director | Sale of securities on an exchange or to another person at price $ 122.93 per share. | 11 Mar 2024 | 761 | 7,516 (0%) | 0% | 122.9 | 93,550 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.90 per share. | 08 Mar 2024 | 15,000 | 37,840 (0%) | 0% | 13.9 | 208,500 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 15,000 | 0 | - | - | Stock Option (right to buy) | |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 122.39 per share. | 08 Mar 2024 | 100 | 22,840 (0%) | 0% | 122.4 | 12,239 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 123.10 per share. | 08 Mar 2024 | 11,745 | 22,940 (0%) | 0% | 123.1 | 1,445,810 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 123.85 per share. | 08 Mar 2024 | 3,155 | 34,685 (0%) | 0% | 123.9 | 390,747 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 120.49 per share. | 07 Mar 2024 | 512 | 68,982 (0%) | 0% | 120.5 | 61,691 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.14 per share. | 07 Mar 2024 | 909 | 68,073 (0%) | 0% | 123.1 | 111,934 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.14 per share. | 07 Mar 2024 | 1,035 | 36,164 (0%) | 0% | 123.1 | 127,450 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 120.49 per share. | 07 Mar 2024 | 526 | 37,199 (0%) | 0% | 120.5 | 63,378 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.14 per share. | 07 Mar 2024 | 899 | 28,688 (0%) | 0% | 123.1 | 110,703 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 120.49 per share. | 07 Mar 2024 | 506 | 29,587 (0%) | 0% | 120.5 | 60,968 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.14 per share. | 07 Mar 2024 | 472 | 25,222 (0%) | 0% | 123.1 | 58,122 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 120.49 per share. | 07 Mar 2024 | 506 | 25,694 (0%) | 0% | 120.5 | 60,968 | Common Stock |
| Stephen L. Mayo | Director | Sale of securities on an exchange or to another person at price $ 122.96 per share. | 05 Mar 2024 | 3,135 | 6,621 (0%) | 0% | 123.0 | 385,480 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 125.32 per share. | 04 Mar 2024 | 1,728 | 69,494 (0%) | 0% | 125.3 | 216,553 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 125.32 per share. | 04 Mar 2024 | 1,389 | 37,725 (0%) | 0% | 125.3 | 174,069 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 125.32 per share. | 04 Mar 2024 | 1,734 | 30,093 (0%) | 0% | 125.3 | 217,305 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 125.32 per share. | 04 Mar 2024 | 237 | 26,200 (0%) | 0% | 125.3 | 29,701 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 125.32 per share. | 04 Mar 2024 | 285 | 26,437 (0%) | 0% | 125.3 | 35,716 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,846 | 176,839 (0%) | 0% | 0 | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,679 | 3,679 | - | - | Stock Option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,679 | 3,679 | - | - | Stock Option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,846 | 18,174 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2024 | 3,679 | 3,679 | - | - | Stock Option (right to buy) | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,846 | 22,840 (0%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,846 | 2,931,688 (3%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,679 | 3,679 | - | - | Stock Option (right to buy) | |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,846 | 8,277 (0%) | 0% | 0 | Common Stock | |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,679 | 3,679 | - | - | Stock Option (right to buy) | |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 126.19 per share. | 01 Mar 2024 | 778 | 65,222 (0%) | 0% | 126.2 | 98,176 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 6,000 | 71,222 (0%) | 0% | 0 | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 128.30 per share. | 01 Mar 2024 | 1,200 | 39,114 (0%) | 0% | 128.3 | 153,960 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 126.19 per share. | 01 Mar 2024 | 365 | 34,314 (0%) | 0% | 126.2 | 46,059 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 6,000 | 40,314 (0%) | 0% | 0 | Common Stock | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,679 | 3,679 | - | - | Stock Option (right to buy) | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,846 | 9,756 (0%) | 0% | 0 | Common Stock | |
| Ryan Edward Brown | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 125.34 per share. | 01 Mar 2024 | 2,000 | 31,827 (0%) | 0% | 125.3 | 250,680 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Ryan Edward Brown | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 126.19 per share. | 01 Mar 2024 | 269 | 27,827 (0%) | 0% | 126.2 | 33,945 | Common Stock |
| Ryan Edward Brown | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 6,000 | 33,827 (0%) | 0% | 0 | Common Stock | |
| Michael Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,846 | 8,277 (0%) | 0% | 0 | Common Stock | |
| Michael Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,679 | 3,679 | - | - | Stock Option (right to buy) | |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 129.71 per share. | 01 Mar 2024 | 457 | 26,836 (0%) | 0% | 129.7 | 59,277 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 128.58 per share. | 01 Mar 2024 | 1,543 | 27,293 (0%) | 0% | 128.6 | 198,399 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 6,000 | 28,836 (0%) | 0% | 0 | Common Stock | |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 126.19 per share. | 01 Mar 2024 | 251 | 22,836 (0%) | 0% | 126.2 | 31,674 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 126.19 per share. | 01 Mar 2024 | 114 | 26,722 (0%) | 0% | 126.2 | 14,386 | Common Stock |
| Arif Bilal | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.34 per share. | 01 Dec 2023 | 3,682 | 22,886 (0%) | 0% | 80.3 | 295,812 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 109.89 per share. | 14 Aug 2023 | 4,032 | 246,996 (0%) | 0% | 109.9 | 443,076 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 109.19 per share. | 14 Aug 2023 | 5,947 | 242,964 (0%) | 0% | 109.2 | 649,353 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 108.05 per share. | 11 Aug 2023 | 23,686 | 237,017 (0%) | 0% | 108.0 | 2,559,272 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 106.26 per share. | 10 Aug 2023 | 31,570 | 213,331 (0%) | 0% | 106.3 | 3,354,628 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 104.67 per share. | 10 Aug 2023 | 2,206 | 180,670 (0%) | 0% | 104.7 | 230,902 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 105.90 per share. | 10 Aug 2023 | 1,091 | 181,761 (0%) | 0% | 105.9 | 115,537 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.03 per share. | 04 Aug 2023 | 15,000 | 35,994 (0%) | 0% | 29.0 | 435,450 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 106.72 per share. | 04 Aug 2023 | 15,000 | 20,994 (0%) | 0% | 106.7 | 1,600,800 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Aug 2023 | 15,000 | 0 | - | - | Stock Option (right to buy) | |
| Ryan Edward Brown | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.60 per share. | 01 Jun 2023 | 89 | 28,096 (0%) | 0% | 123.6 | 11,000 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 136.66 per share. | 30 Mar 2023 | 307 | 26,367 (0%) | 0% | 136.7 | 41,955 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.19 per share. | 08 Mar 2023 | 912 | 70,170 (0%) | 0% | 153.2 | 139,709 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.19 per share. | 08 Mar 2023 | 744 | 34,679 (0%) | 0% | 153.2 | 113,973 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.19 per share. | 08 Mar 2023 | 635 | 28,185 (0%) | 0% | 153.2 | 97,276 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.19 per share. | 08 Mar 2023 | 314 | 26,674 (0%) | 0% | 153.2 | 48,102 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 3,257 | 3,257 | - | - | Stock Option (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 1,523 | 159,993 (0%) | 0% | 0 | Common Stock | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 3,257 | 3,257 | - | - | Stock Option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 1,523 | 16,328 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 1,523 | 20,994 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 3,257 | 3,257 | - | - | Stock Option (right to buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 1,523 | 2,929,842 (3%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 3,257 | 3,257 | - | - | Stock Option (right to buy) | |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 1,523 | 6,431 (0%) | 0% | 0 | Common Stock | |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 3,257 | 3,257 | - | - | Stock Option (right to buy) | |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 4,500 | 71,082 (0%) | 0% | 0 | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.21 per share. | 06 Mar 2023 | 1,134 | 66,582 (0%) | 0% | 157.2 | 178,276 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 4,500 | 35,423 (0%) | 0% | 0 | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.21 per share. | 06 Mar 2023 | 1,370 | 30,923 (0%) | 0% | 157.2 | 215,378 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 3,257 | 3,257 | - | - | Stock Option (right to buy) | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 1,523 | 7,910 (0%) | 0% | 0 | Common Stock | |
| Ryan Edward Brown | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.21 per share. | 06 Mar 2023 | 1,154 | 24,491 (0%) | 0% | 157.2 | 181,420 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.21 per share. | 06 Mar 2023 | 171 | 24,320 (0%) | 0% | 157.2 | 26,883 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 4,500 | 28,820 (0%) | 0% | 0 | Common Stock | |
| Michael Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 1,523 | 6,431 (0%) | 0% | 0 | Common Stock | |
| Michael Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 3,257 | 3,257 | - | - | Stock Option (right to buy) | |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 4,500 | 26,988 (0%) | 0% | 0 | Common Stock | |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.21 per share. | 06 Mar 2023 | 154 | 22,488 (0%) | 0% | 157.2 | 24,210 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.21 per share. | 06 Mar 2023 | 186 | 22,642 (0%) | 0% | 157.2 | 29,241 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 147.57 per share. | 01 Mar 2023 | 522 | 67,716 (0%) | 0% | 147.6 | 77,032 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 147.57 per share. | 01 Mar 2023 | 378 | 32,293 (0%) | 0% | 147.6 | 55,781 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 147.57 per share. | 01 Mar 2023 | 196 | 25,645 (0%) | 0% | 147.6 | 28,924 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 147.58 per share. | 01 Mar 2023 | 80 | 22,837 (0%) | 0% | 147.6 | 11,806 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 147.57 per share. | 01 Mar 2023 | 172 | 22,828 (0%) | 0% | 147.6 | 25,382 | Common Stock |
| Bilal Arif | Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2022 | 30,000 | 30,000 | - | - | Stock Option (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2022 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.92 per share. | 19 Dec 2022 | 20,000 | 158,470 (0%) | 0% | 34.9 | 698,400 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 108.52 per share. | 17 Nov 2022 | 4,211 | 67,998 (0%) | 0% | 108.5 | 456,978 | Common Stock |
| Stephen L. Mayo | Director | Sale of securities on an exchange or to another person at price $ 109.92 per share. | 17 Nov 2022 | 858 | 6,387 (0%) | 0% | 109.9 | 94,311 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 103.87 per share. | 14 Sep 2022 | 20,744 | 71,822 (0%) | 0% | 103.9 | 2,154,679 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 105.16 per share. | 14 Sep 2022 | 6,250 | 108,178 (0%) | 0% | 105.2 | 657,250 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 104.67 per share. | 14 Sep 2022 | 30,106 | 101,928 (0%) | 0% | 104.7 | 3,151,195 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 108.80 per share. | 19 Aug 2022 | 6,060 | 51,078 (0%) | 0% | 108.8 | 659,328 | Common Stock |
| Michael Chambers | Director | Purchase of securities on an exchange or from another person at price $ 108.20 per share. | 19 Aug 2022 | 40,110 | 45,018 (0%) | 0% | 108.2 | 4,339,902 | Common Stock |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 8,329 | 8,329 | - | - | Stock Option (right to buy) | |
| Kathryn Jean Boor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 4,908 | 4,908 (0%) | 0% | 0 | Common Stock | |
| Michael Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 8,329 | 8,329 | - | - | Stock Option (right to buy) | |
| Michael Chambers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 4,908 | 4,908 (0%) | 0% | 0 | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 5,077 | 5,077 | - | - | Stock Option (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 2,953 | 138,470 (0%) | 0% | 0 | Common Stock | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 5,077 | 5,077 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 2,953 | 12,356 (0%) | 0% | 0 | Common Stock | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 5,077 | 5,077 | - | - | Stock Option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 2,953 | 14,805 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 5,077 | 5,077 | - | - | Stock Option (right to buy) | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 2,953 | 19,471 (0%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 5,077 | 5,077 | - | - | Stock Option (right to buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 2,953 | 2,928,319 (3%) | 0% | 0 | Common Stock | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 5,077 | 5,077 | - | - | Stock Option (right to buy) | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2022 | 2,953 | 7,245 (0%) | 0% | 0 | Common Stock | |
| William Ciambrone | EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 8,000 | 22,099 (0%) | 0% | 0 | Common Stock | |
| William Ciambrone | EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 48,000 | 48,000 | - | - | Stock Option (right to buy) | |
| William Ciambrone | EVP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.20 per share. | 04 Mar 2022 | 1,160 | 14,099 (0%) | 0% | 79.2 | 91,872 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.20 per share. | 04 Mar 2022 | 1,216 | 64,111 (0%) | 0% | 79.2 | 96,307 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 48,000 | 48,000 | - | - | Stock Option (right to buy) | |
| Louise Rodino-Klapac | Head of R&D, CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 8,000 | 72,111 (0%) | 0% | 0 | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 8,000 | 32,671 (0%) | 0% | 0 | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 48,000 | 48,000 | - | - | Stock Option (right to sell) | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.36 per share. | 04 Mar 2022 | 398 | 24,671 (0%) | 0% | 79.4 | 31,585 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.20 per share. | 04 Mar 2022 | 1,308 | 25,069 (0%) | 0% | 79.2 | 103,594 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 48,000 | 48,000 | - | - | Stock Option (right to buy) | |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.36 per share. | 04 Mar 2022 | 153 | 17,895 (0%) | 0% | 79.4 | 12,142 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 8,000 | 25,895 (0%) | 0% | 0 | Common Stock | |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.20 per share. | 04 Mar 2022 | 1,136 | 18,048 (0%) | 0% | 79.2 | 89,971 | Common Stock |
| Louise Rodino-Klapac | Head of R&D, CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 75.05 per share. | 01 Mar 2022 | 572 | 65,327 (0%) | 0% | 75.1 | 42,929 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 75.05 per share. | 01 Mar 2022 | 376 | 26,377 (0%) | 0% | 75.1 | 28,219 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 75.05 per share. | 01 Mar 2022 | 184 | 19,184 (0%) | 0% | 75.0 | 13,809 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.08 per share. | 15 Dec 2021 | 5,000 | 135,517 (0%) | 0% | 10.1 | 50,400 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2021 | 5,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Mary Ann Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2021 | 967 | 0 | - | - | Restricted Stock Units | |
| Mary Ann Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2021 | 967 | 9,403 (0%) | 0% | 0 | Common Stock | |
| Louise Rodino-Klapac | Head of R&D, CSO | Purchase of securities on an exchange or from another person at price $ 79.33 per share. | 24 Nov 2021 | 3,780 | 65,678 (0%) | 0% | 79.3 | 299,867 | Common Stock |
| Douglas S. Ingram | Director, President & CEO | Purchase of securities on an exchange or from another person at price $ 79.94 per share. | 17 Nov 2021 | 25,026 | 365,082 (0%) | 0% | 79.9 | 2,000,578 | Common Stock |
| Louise Rodino-Klapac | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Nov 2021 | 40,000 | 61,898 (0%) | 0% | 0 | Common Stock | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Nov 2021 | 4,292 | 4,292 (0%) | 0% | 0 | Common Stock | |
| Stephen L. Mayo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Nov 2021 | 8,238 | 8,238 | - | - | Stock Option (right to buy) | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.29 per share. | 08 Sep 2021 | 1,623 | 26,753 (0%) | 0% | 78.3 | 127,065 | Common Stock |
| Douglas S. Ingram | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.40 per share. | 26 Jun 2021 | 17,812 | 340,056 (0%) | 0% | 80.4 | 1,432,085 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 76.02 per share. | 01 Jun 2021 | 64 | 19,368 (0%) | 0% | 76.0 | 4,865 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Sale of securities on an exchange or to another person at price $ 85.76 per share. | 10 Mar 2021 | 5,000 | 130,517 (0%) | 0% | 85.8 | 428,800 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.30 per share. | 10 Mar 2021 | 5,000 | 135,517 (0%) | 0% | 42.3 | 211,500 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 5,000 | 0 | - | - | Stock Option (right to buy) | |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.92 per share. | 08 Mar 2021 | 10,000 | 26,518 (0%) | 0% | 34.9 | 349,200 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2021 | 10,000 | 0 | - | - | Stock Option (right to buy) | |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 83.51 per share. | 08 Mar 2021 | 10,000 | 16,518 (0%) | 0% | 83.5 | 835,100 | Common Stock |
| John C. Martin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 5,518 | 5,518 | - | - | Stock Option (right to buy) | |
| John C. Martin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 2,726 | 7,913 (0%) | 0% | 0 | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 2,726 | 130,517 (0%) | 0% | 0 | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 5,518 | 5,518 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 2,726 | 8,436 (0%) | 0% | 0 | Common Stock | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 5,518 | 5,518 | - | - | Stock Option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 5,518 | 5,518 | - | - | Stock Option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 2,726 | 11,852 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 2,726 | 16,518 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 5,518 | 5,518 | - | - | Stock Option (right to buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 2,726 | 3,125,366 (4%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 5,518 | 5,518 | - | - | Stock Option (right to buy) | |
| William Ciambrone | EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 15,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| William Ciambrone | EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2021 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Gilmore O'Neill | EVP, R&D & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 86.97 per share. | 28 Feb 2021 | 524 | 13,546 (0%) | 0% | 87.0 | 45,572 | Common Stock |
| Gilmore O'Neill | EVP, R&D & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2021 | 15,000 | 28,546 (0%) | 0% | 0 | Common Stock | |
| Louise Rodino-Klapac | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 86.97 per share. | 28 Feb 2021 | 565 | 6,604 (0%) | 0% | 87.0 | 49,138 | Common Stock |
| Louise Rodino-Klapac | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2021 | 15,000 | 21,780 (0%) | 0% | 0 | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2021 | 15,000 | 28,723 (0%) | 0% | 0 | Common Stock | |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 84.65 per share. | 28 Feb 2021 | 347 | 28,376 (0%) | 0% | 84.7 | 29,374 | Common Stock |
| Ian Michael Estepan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 86.97 per share. | 28 Feb 2021 | 319 | 13,723 (0%) | 0% | 87.0 | 27,743 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 86.97 per share. | 28 Feb 2021 | 216 | 4,622 (0%) | 0% | 87.0 | 18,786 | Common Stock |
| Ryan Edward Brown | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2021 | 15,000 | 19,622 (0%) | 0% | 0 | Common Stock | |
| Ryan Edward Brown | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.76 per share. | 28 Feb 2021 | 190 | 19,432 (0%) | 0% | 80.8 | 15,344 | Common Stock |
| Louise Rodino-Klapac | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2020 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Ian Michael Estepan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2020 | 25,000 | 25,000 | - | - | Stock option (right to buy) | |
| Joseph Bratica | Principal Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 71.45 per share. | 11 Dec 2020 | 1,115 | 9,255 (0%) | 0% | 71.5 | 79,667 | Common Stock |
| Joseph Bratica | Principal Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2020 | 1,115 | 12,285 | - | - | Stock Option (right to buy) | |
| Joseph Bratica | Principal Financial Officer | Sale of securities on an exchange or to another person at price $ 165.00 per share. | 11 Dec 2020 | 1,115 | 8,140 (0%) | 0% | 165 | 183,975 | Common Stock |
| Mary Ann Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2020 | 967 | 5,710 (0%) | 0% | 0 | Common Stock | |
| Mary Ann Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2020 | 967 | 967 | - | - | Restricted Stock Units | |
| Joseph Bratica | Principal Financial Officer | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 08 Dec 2020 | 1,125 | 8,140 (0%) | 0% | 160 | 180,000 | Common Stock |
| Joseph Bratica | Principal Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2020 | 1,125 | 4,500 | - | - | Stock Option (right to buy) | |
| Joseph Bratica | Principal Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.60 per share. | 08 Dec 2020 | 1,125 | 9,265 (0%) | 0% | 29.6 | 33,300 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 159.65 per share. | 10 Aug 2020 | 777 | 13,792 (0%) | 0% | 159.6 | 124,048 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.92 per share. | 10 Aug 2020 | 10,000 | 23,792 (0%) | 0% | 34.9 | 349,200 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2020 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 158.95 per share. | 10 Aug 2020 | 9,223 | 14,569 (0%) | 0% | 159.0 | 1,465,996 | Common Stock |
| Richard J. Barry | Director | Sale of securities on an exchange or to another person at price $ 158.43 per share. | 07 Aug 2020 | 26,860 | 3,132,280 (4%) | 0% | 158.4 | 4,255,430 | Common Stock |
| Richard J. Barry | Director | Sale of securities on an exchange or to another person at price $ 159.09 per share. | 07 Aug 2020 | 3,140 | 3,129,140 (4%) | 0% | 159.1 | 499,543 | Common Stock |
| Joseph Bratica | Principal Financial Officer | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 03 Aug 2020 | 1,125 | 7,832 (0%) | 0% | 155 | 174,375 | Common Stock |
| Joseph Bratica | Principal Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.60 per share. | 03 Aug 2020 | 1,125 | 8,957 (0%) | 0% | 29.6 | 33,300 | Common Stock |
| Joseph Bratica | Principal Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2020 | 1,125 | 5,625 | - | - | Stock Option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.03 per share. | 22 Jun 2020 | 45,000 | 136,993 (0%) | 0% | 29.0 | 1,306,350 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 22 Jun 2020 | 1,280 | 33,151 (0%) | 0% | 13.7 | 17,549 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 22 Jun 2020 | 1,858 | 35,009 (0%) | 0% | 13.7 | 25,473 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.85 per share. | 22 Jun 2020 | 56,984 | 91,993 (0%) | 0% | 23.8 | 1,359,068 | Common Stock |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 168.61 per share. | 22 Jun 2020 | 6,009 | 130,984 (0%) | 0% | 168.6 | 1,013,177 | Common Stock |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 169.56 per share. | 22 Jun 2020 | 8,086 | 122,898 (0%) | 0% | 169.6 | 1,371,062 | Common Stock |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 170.59 per share. | 22 Jun 2020 | 35,757 | 87,141 (0%) | 0% | 170.6 | 6,099,787 | Common Stock |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 171.50 per share. | 22 Jun 2020 | 55,270 | 31,871 (0%) | 0% | 171.5 | 9,478,805 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2020 | 1,280 | 0 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2020 | 1,858 | 0 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2020 | 56,984 | 0 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2020 | 45,000 | 7,708 | - | - | Stock option (right to buy) | |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2020 | 5,000 | 0 | - | - | Stock Oprion (right to buy) | |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.08 per share. | 20 May 2020 | 5,000 | 18,792 (0%) | 0% | 10.1 | 50,400 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 149.62 per share. | 20 May 2020 | 2,100 | 16,692 (0%) | 0% | 149.6 | 314,202 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 151.22 per share. | 20 May 2020 | 2,046 | 14,646 (0%) | 0% | 151.2 | 309,396 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 151.77 per share. | 20 May 2020 | 854 | 13,792 (0%) | 0% | 151.8 | 129,612 | Common Stock |
| Richard J. Barry | Director | Sale of securities on an exchange or to another person at price $ 141.12 per share. | 15 May 2020 | 25,327 | 3,163,813 (4%) | 0% | 141.1 | 3,574,146 | Common Stock |
| Richard J. Barry | Director | Sale of securities on an exchange or to another person at price $ 142.05 per share. | 15 May 2020 | 4,673 | 3,159,140 (4%) | 0% | 142.1 | 663,800 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Gift of securities by or to the insider at price $ 0.00 per share. | 11 May 2020 | 20,425 | 16,454 (0%) | 0% | 0 | Common Stock | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2020 | 1,203 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 11 May 2020 | 218 | 19,057 (0%) | 0% | 13.7 | 2,989 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.63 per share. | 11 May 2020 | 1,203 | 20,260 (0%) | 0% | 32.6 | 39,254 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2020 | 2,385 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2020 | 218 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 11 May 2020 | 2,385 | 18,839 (0%) | 0% | 13.7 | 32,698 | Common Stock |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 116.89 per share. | 04 Mar 2020 | 5,000 | 13,792 (0%) | 0% | 116.9 | 584,450 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2020 | 5,000 | 0 | - | - | Stock option (right to buy) | |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.46 per share. | 04 Mar 2020 | 5,000 | 18,792 (0%) | 0% | 8.5 | 42,300 | Common Stock |
| Michael W. Bonney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 3,685 | 3,685 | - | - | Stock option (right to buy) | |
| Michael W. Bonney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 2,075 | 9,126 (0%) | 0% | 0 | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 3,685 | 3,685 | - | - | Stock option (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 2,075 | 127,742 (0%) | 0% | 0 | Common Stock | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 3,685 | 3,685 | - | - | Stock option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 2,075 | 4,743 (0%) | 0% | 0 | Common Stock | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 3,685 | 3,685 | - | - | Stock option (right to buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 2,075 | 9,126 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 2,075 | 13,792 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 3,685 | 3,685 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 37,500 | 37,500 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 6,700 | 31,871 (0%) | 0% | 0 | Common Stock | |
| Sandesh Mahatme | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 6,700 | 36,879 (0%) | 0% | 0 | Common Stock | |
| Sandesh Mahatme | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 37,500 | 37,500 | - | - | Stock option (right to buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 2,075 | 3,189,140 (4%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 3,685 | 3,685 | - | - | Stock option (right to buy) | |
| Alexander Cumbo | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 37,500 | 37,500 | - | - | Stock option (right to buy) | |
| Alexander Cumbo | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 6,700 | 8,567 (0%) | 0% | 0 | Common Stock | |
| Gilmore O'Neill | EVP, R&D & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 37,500 | 37,500 | - | - | Stock option (right to buy) | |
| Gilmore O'Neill | EVP, R&D & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 6,700 | 14,070 (0%) | 0% | 0 | Common Stock | |
| Douglas S. Ingram | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 129.04 per share. | 31 Dec 2019 | 37,185 | 395,012 (0%) | 0% | 129.0 | 4,798,352 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.90 per share. | 13 Dec 2019 | 18,579 | 43,750 (0%) | 0% | 13.9 | 258,248 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 59,421 | 56,984 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 18,579 | 0 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 125.50 per share. | 13 Dec 2019 | 78,000 | 25,171 (0%) | 0% | 125.5 | 9,789,000 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.85 per share. | 13 Dec 2019 | 59,421 | 103,171 (0%) | 0% | 23.9 | 1,417,191 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.63 per share. | 13 Dec 2019 | 21,875 | 140,456 (0%) | 0% | 32.6 | 713,781 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.03 per share. | 13 Dec 2019 | 69,479 | 118,581 (0%) | 0% | 29.0 | 2,016,975 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.85 per share. | 13 Dec 2019 | 10,466 | 49,102 (0%) | 0% | 23.8 | 249,614 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 13 Dec 2019 | 4,138 | 38,636 (0%) | 0% | 13.7 | 56,732 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 13 Dec 2019 | 4,319 | 34,498 (0%) | 0% | 13.7 | 59,213 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 14,723 | 39,277 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 21,875 | 10,874 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 69,479 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 10,466 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 4,138 | 2,633 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 4,319 | 3,085 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Sale of securities on an exchange or to another person at price $ 125.50 per share. | 13 Dec 2019 | 125,000 | 30,179 (0%) | 0% | 125.5 | 15,687,500 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.92 per share. | 13 Dec 2019 | 14,723 | 155,179 (0%) | 0% | 34.9 | 514,127 | Common Stock |
| Alexander Cumbo | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 125.50 per share. | 13 Dec 2019 | 32,706 | 11,161 (0%) | 0% | 125.5 | 4,104,603 | Common Stock |
| Alexander Cumbo | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.24 per share. | 13 Dec 2019 | 26,084 | 43,867 (0%) | 0% | 26.2 | 684,444 | Common Stock |
| Alexander Cumbo | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 13 Dec 2019 | 3,895 | 17,783 (0%) | 0% | 13.7 | 53,400 | Common Stock |
| Alexander Cumbo | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 13 Dec 2019 | 2,727 | 13,888 (0%) | 0% | 13.7 | 37,387 | Common Stock |
| Alexander Cumbo | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 26,084 | 20,881 | - | - | Stock option (right to buy) | |
| Alexander Cumbo | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 3,895 | 0 | - | - | Stock option (right to buy) | |
| Alexander Cumbo | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 2,727 | 1,123 | - | - | Stock option (right to buy) | |
| Alexander Cumbo | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 125.50 per share. | 13 Dec 2019 | 9,294 | 1,867 (0%) | 0% | 125.5 | 1,166,397 | Common Stock |
| Mary Ann Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2019 | 967 | 1,934 | - | - | Restricted Stock Units | |
| Mary Ann Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2019 | 967 | 2,668 (0%) | 0% | - | Common Stock | |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 105.00 per share. | 22 Nov 2019 | 18,290 | 18,703 (0%) | 0% | 105 | 1,920,450 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2019 | 7,900 | 5,118 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2019 | 5,590 | 0 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2019 | 52 | 18 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2019 | 2,440 | 2,470 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2019 | 8,580 | 18,579 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2019 | 4,025 | 1,858 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2019 | 5,685 | 1,280 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 107.02 per share. | 22 Nov 2019 | 2,804 | 25,171 (0%) | 0% | 107.0 | 300,084 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.85 per share. | 22 Nov 2019 | 7,900 | 27,975 (0%) | 0% | 23.9 | 188,415 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.90 per share. | 22 Nov 2019 | 5,590 | 20,075 (0%) | 0% | 13.9 | 77,701 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 22 Nov 2019 | 52 | 14,485 (0%) | 0% | 13.7 | 713 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 22 Nov 2019 | 2,440 | 14,433 (0%) | 0% | 13.7 | 33,452 | Common Stock |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 105.00 per share. | 22 Nov 2019 | 2,957 | 11,993 (0%) | 0% | 105 | 310,485 | Common Stock |
| David T. Howton | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 105.00 per share. | 22 Nov 2019 | 3,753 | 14,950 (0%) | 0% | 105 | 394,065 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.90 per share. | 22 Nov 2019 | 8,580 | 36,993 (0%) | 0% | 13.9 | 119,262 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 22 Nov 2019 | 4,025 | 28,413 (0%) | 0% | 13.7 | 55,183 | Common Stock |
| David T. Howton | EVP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 22 Nov 2019 | 5,685 | 24,388 (0%) | 0% | 13.7 | 77,941 | Common Stock |
| William Ciambrone | EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2019 | 80,000 | 80,000 | - | - | Stock option (right to buy) | |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 87.49 per share. | 12 Sep 2019 | 3,309 | 3,187,065 (4%) | 0% | 87.5 | 289,504 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 87.49 per share. | 12 Sep 2019 | 1,691 | 3,183,756 (4%) | 0% | 87.5 | 147,950 | Common Stock |
| Michael W. Bonney | Director | Purchase of securities on an exchange or from another person at price $ 86.74 per share. | 09 Sep 2019 | 2,000 | 7,051 (0%) | 0% | 86.7 | 173,480 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Purchase of securities on an exchange or from another person at price $ 87.98 per share. | 05 Sep 2019 | 2,500 | 125,667 (0%) | 0% | 88.0 | 219,950 | Common Stock |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Sep 2019 | 5,000 | 0 | - | - | Stock Option (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.80 per share. | 05 Sep 2019 | 5,000 | 123,167 (0%) | 0% | 7.8 | 39,000 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.85 per share. | 21 Aug 2019 | 100,000 | 130,179 (0%) | 0% | 23.9 | 2,385,000 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2019 | 100,000 | 0 | - | - | Stock Appreciation Right | |
| Sandesh Mahatme | EVP, CFO & CBO | Gift of securities by or to the insider at price $ 0.00 per share. | 21 Aug 2019 | 42,535 | 30,179 (0%) | 0% | 0 | Common Stock | |
| Sandesh Mahatme | EVP, CFO & CBO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.50 per share. | 21 Aug 2019 | 57,465 | 72,714 (0%) | 0% | 101.5 | 5,832,698 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 99.32 per share. | 20 Aug 2019 | 5,000 | 3,182,065 (4%) | 0% | 99.3 | 496,593 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.03 per share. | 15 Aug 2019 | 3,021 | 26,309 (0%) | 0% | 29.0 | 87,700 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2019 | 260 | 218 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2019 | 985 | 2,385 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2019 | 2,625 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2019 | 3,021 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2019 | 2,863 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 15 Aug 2019 | 260 | 30,179 (0%) | 0% | 13.7 | 3,565 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 15 Aug 2019 | 985 | 29,919 (0%) | 0% | 13.7 | 13,504 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.92 per share. | 15 Aug 2019 | 2,863 | 23,288 (0%) | 0% | 34.9 | 99,976 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.90 per share. | 15 Aug 2019 | 2,625 | 28,934 (0%) | 0% | 13.9 | 36,488 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 122.50 per share. | 14 Aug 2019 | 3,700 | 3,177,065 (4%) | 0% | 122.5 | 453,250 | Common Stock |
| Douglas S. Ingram | Director, President & CEO | Purchase of securities on an exchange or from another person at price $ 123.41 per share. | 12 Aug 2019 | 7,792 | 432,197 (0%) | 0% | 123.4 | 961,611 | Common Stock |
| Douglas S. Ingram | Director, President & CEO | Purchase of securities on an exchange or from another person at price $ 122.76 per share. | 12 Aug 2019 | 8,460 | 424,405 (0%) | 0% | 122.8 | 1,038,550 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 122.50 per share. | 12 Aug 2019 | 1,300 | 3,173,365 (4%) | 0% | 122.5 | 159,250 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2019 | 10,000 | 0 | - | - | Stock Option (right to buy) | |
| Hans Wigzell | Director | Sale of securities on an exchange or to another person at price $ 120.00 per share. | 23 May 2019 | 10,000 | 11,717 (0%) | 0% | 120 | 1,200,000 | Common Stock |
| Hans Wigzell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.80 per share. | 23 May 2019 | 10,000 | 21,717 (0%) | 0% | 7.8 | 78,000 | Common Stock |
| Gilmore O'Neill | EVP, R&D & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 119.31 per share. | 23 May 2019 | 4,630 | 7,370 (0%) | 0% | 119.3 | 552,405 | Common Stock |
| Gilmore O'Neill | EVP, R&D & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2019 | 12,000 | 0 | - | - | Restricted Stock Units | |
| Gilmore O'Neill | EVP, R&D & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2019 | 12,000 | 12,000 (0%) | 0% | - | Common Stock | |
| David T. Howton | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 118.68 per share. | 28 Mar 2019 | 2,362 | 18,703 (0%) | 0% | 118.7 | 280,322 | Common Stock |
| David T. Howton | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2019 | 5,319 | 21,065 (0%) | 0% | 0 | Common Stock | |
| Sandesh Mahatme | EVP, CFO & CBO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 118.68 per share. | 28 Mar 2019 | 2,953 | 20,425 (0%) | 0% | 118.7 | 350,462 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2019 | 6,649 | 23,378 (0%) | 0% | 0 | Common Stock | |
| Alexander Cumbo | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 118.68 per share. | 28 Mar 2019 | 2,165 | 11,161 (0%) | 0% | 118.7 | 256,942 | Common Stock |
| Alexander Cumbo | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2019 | 4,876 | 13,326 (0%) | 0% | 0 | Common Stock | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.90 per share. | 19 Mar 2019 | 3,511 | 19,147 (0%) | 0% | 13.9 | 48,803 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2019 | 43 | 478 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2019 | 164 | 3,370 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2019 | 3,511 | 2,625 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2019 | 11,768 | 0 | - | - | Stock option (right to buy) | |
| Sandesh Mahatme | EVP, CFO & CBO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 126.47 per share. | 19 Mar 2019 | 2,625 | 16,729 (0%) | 0% | 126.5 | 331,984 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.72 per share. | 19 Mar 2019 | 43 | 19,354 (0%) | 0% | 13.7 | 590 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.71 per share. | 19 Mar 2019 | 164 | 19,311 (0%) | 0% | 13.7 | 2,248 | Common Stock |
| Sandesh Mahatme | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.85 per share. | 19 Mar 2019 | 11,768 | 15,636 (0%) | 0% | 23.9 | 280,667 | Common Stock |
| Michael W. Bonney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 3,213 | 3,213 | - | - | Stock option (right to buy) | |
| Michael W. Bonney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 1,633 | 5,051 (0%) | 0% | 0 | Common Stock | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 3,213 | 3,213 | - | - | Stock option (right to buy) | |
| M. Kathleen Behrens Wilsey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 1,633 | 118,167 (0%) | 0% | 0 | Common Stock | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 3,213 | 3,213 | - | - | Stock option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 1,633 | 1,701 (0%) | 0% | 0 | Common Stock | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 1,633 | 7,051 (0%) | 0% | 0 | Common Stock | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 3,213 | 3,213 | - | - | Stock option (right to buy) | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 1,633 | 11,717 (0%) | 0% | 0 | Common Stock | |
| Hans Wigzell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 3,213 | 3,213 | - | - | Stock option (right to buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 1,633 | 3,172,065 (4%) | 0% | 0 | Common Stock | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 3,213 | 3,213 | - | - | Stock option (right to buy) | |
| Gilmore O'Neill | EVP, R&D & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2019 | 55,000 | 55,000 | - | - | Stock option (right to buy) | |
| David T. Howton | EVP, General Counsel | Sale or transfer of securities back to the company at price $ 0.00 per share. | 28 Feb 2019 | 3,825 | 15,746 (0%) | 0% | 0 | Common Stock |